A systematic review and meta-analyses of commercially available viral and bacterial vaccines for bovine respiratory disease complex: Realizing gaps in recommendations from existing immunization guidelines

Miles Theurer, DVM, PhD

Kansas State University, United States

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Vaccination of cattle is routine procedure in the beef industry with the goal to suppress and delay the severity of bovine respiratory disease complex (BRDC). Bovine respiratory disease is a multi-factorial disease with one of the primary causes due to viral or bacterial infection. We performed a systematic review and meta-analysis to evaluate the efficacy of vaccinating cattle with commercially available viral and bacterial agents to mitigate the effects of BRDC. Determination of clinical efficacy from induced-disease challenge models requires caution as induction models are different from natural exposure. The published literature provides some guidance for veterinarians, but does not provide definitive recommendations for which viral and/or bacterial components are necessary for a vaccination program. This presentation will discuss the outcomes of this review as well as the challenges in the design, execution and publication of systematic reviews in veterinary medicine.

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